Study of interaction of polystyrene sulfonate with polymerization degree of 8 and polyallylamine with bilayer lipids membranes
Identifieur interne : 000B06 ( Main/Exploration ); précédent : 000B05; suivant : 000B07Study of interaction of polystyrene sulfonate with polymerization degree of 8 and polyallylamine with bilayer lipids membranes
Auteurs : S. V. Artyushenko [Russie] ; N. A. Kontarov [Russie] ; N. V. Yuminova [Russie]Source :
- Biophysics [ 0006-3509 ] ; 2012-03-01.
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Abstract
Abstract: Interaction of polystyrene sulfonate (polymerization degree of 8, PSS-8) and polyallylamine (PAA, mol. mass 60 kDa) with viruses of the para- and orthomyxovirus family (on the examples of measles, parotiditis, and influenza viruses) suppresses their infectivity. The possible mechanism of virus-inhibiting action of these chemical compounds is damaging of interfacial antigenic proteins of para- and orthomyxoviruses. In this study we detected the change of surface tension of bilayer lipid membrane in the presence of PSS-8 and PAA. This process could lead to impairment of fusion and self-assembly of virions.
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DOI: 10.1134/S0006350912020029
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The possible mechanism of virus-inhibiting action of these chemical compounds is damaging of interfacial antigenic proteins of para- and orthomyxoviruses. In this study we detected the change of surface tension of bilayer lipid membrane in the presence of PSS-8 and PAA. This process could lead to impairment of fusion and self-assembly of virions.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Artyushenko, S V" sort="Artyushenko, S V" uniqKey="Artyushenko S" first="S. V." last="Artyushenko">S. V. Artyushenko</name></region><name sortKey="Kontarov, N A" sort="Kontarov, N A" uniqKey="Kontarov N" first="N. A." last="Kontarov">N. A. Kontarov</name><name sortKey="Kontarov, N A" sort="Kontarov, N A" uniqKey="Kontarov N" first="N. A." last="Kontarov">N. A. 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